Getting Started
New to OpenBio? Start here to learn the basics and get up and running quickly.Quick Start Guide
Follow our step-by-step guide to get started with OpenBio in minutes.
What’s New
Discover the latest features and enhancements to OpenBio:Data Analysis (Code Mode)
Activate Code Mode for Python-based data analysis, visualizations, and computational tasks. Execute code in a stateful Jupyter environment with pre-installed scientific libraries.
MCP Support
Extend OpenBio capabilities by connecting external MCP servers. Access documentation search, API integrations, and custom tools like Biorender, Synapse, and more.
Zotero Integration
Access and manage your Zotero reference library directly from OpenBio. Search citations, organize papers, and integrate references into your research workflow.
Code Mode Demo
Watch Code Mode in action:Zotero Integration Demo
Watch Zotero integration in action:MCP Integration Demo
Watch how to add BioRender MCP for template search:User Guide Overview
Our comprehensive user guide covers everything you need to know about using OpenBio effectively.Getting Started
Learn how to create an account, sign in, and understand the OpenBio interface.
Core Features
Master chat interactions, project management, file handling, and workflows.
Tools Reference
Complete reference for all available tools.
What You Can Do with OpenBio
OpenBio empowers you to tackle complex biological research tasks with AI assistance:Database Queries
Search and analyze biological databases like PDB, UniProt, ChEMBL, PubMed, and AlphaFold DB using natural language.Structure Prediction
Predict protein structures from sequences using state-of-the-art AI models like Boltz-2 and Chai-1.Molecular Design
Design proteins, optimize stability, create variants, and engineer new molecules.Research Workflows
Automate complex research pipelines and create reproducible protocols.Data Analysis
Use Python code execution for advanced data analysis, visualizations, and computational tasks with Code Mode.Project Organization
Manage files, notes, and research data in organized project workspaces.MCP Integration
Extend OpenBio capabilities by connecting external MCP servers for documentation search, API integrations, and custom tools like Biorender, Synapse, and more.Zotero Integration
Access and manage your Zotero reference library directly from OpenBio, search citations, and organize research papers.Key Features at a Glance
AI-Powered Research Assistant
- Natural language queries for complex biological tasks
- Intelligent tool selection and execution
- Real-time assistance throughout your research workflow
Comprehensive Tool Suite
- Structure prediction (Boltz-2, Chai-1, SimpleFold)
- Protein design (ProteinMPNN, LigandMPNN, ThermoMPNN)
- Molecular chemistry (RDKit, SA Score)
- Database queries (PDB, UniProt, ChEMBL, PubMed, AlphaFold DB)
- And many more specialized tools
Advanced Analysis Capabilities
- Side-by-side comparisons of structures and data
- Interactive 3D visualizations
- Python code execution for data analysis and visualization
- Computational workflows with stateful execution environment
Workflow Automation
- Create reusable research protocols
- Automate repetitive tasks
Research Organization
- Project-based workspace organization
- Integrated note-taking and todo management
- Comprehensive documentation tools
- Zotero reference library integration
- MCP server connections for extended capabilities
Need Help?
Frequently Asked Questions
Find answers to common questions about OpenBio.
Community Support
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Video Tutorials
Watch video tutorials and walkthroughs on our YouTube channel.
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