> ## Documentation Index
> Fetch the complete documentation index at: https://docs.openbio.tech/llms.txt
> Use this file to discover all available pages before exploring further.

# Prediction Tools

> AI-powered structure prediction and protein design tools

OpenBio provides AI models for protein structure prediction, protein design, and molecular modeling.

## Structure Prediction

**Boltz-2**: Highest accuracy protein-ligand co-folding

* Predict protein structures with ligands
* Co-fold multiple chains with ligands

**Chai-1**: Multi-modal structure prediction

* Handles proteins, DNA, RNA, ligands, glycans
* Complex assemblies and multi-component systems

**BoltzGen**: Generative protein design and sampling

* Generate novel protein structures from scratch
* Sample diverse, foldable backbones beyond existing databases
* Explore design space with controllable structural diversity

**SimpleFold**: Fast protein structure prediction

* Quick structure estimates for screening

## Protein Design

**ProteinMPNN**: Design protein sequences from structures

* Redesign existing structures
* Create stabilized variants

**LigandMPNN**: Design sequences considering ligands

* Optimize protein-ligand interactions
* Design enzyme variants

**ThermoMPNN**: Design thermostable variants

* Improve protein stability
* Optimize for high temperatures

**Pinal**: Text-to-protein design

* Create proteins from natural language descriptions
* Modify structures with text instructions

## Docking

**GeoDock**: Protein-protein docking

* Predict protein-protein binding poses

## Quick Examples

* "Predict the structure of this protein using Boltz-2"
* "Design sequences for this structure using ProteinMPNN"
* "Dock this compound to EGFR structure using GeoDock"
* "Create a thermostable variant with ThermoMPNN"

<Check> We're constantly adding new tools and improving existing ones. If you don't see a tool you need, please let us know through our [Discord](https://discord.gg/fd8QbDv9RQ) or [write to us](mailto:info@openbio.tech). </Check>